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The WD Motorcycle forum
don't know if this helps but on my M21 I have a 1 1/16 " Monobloc with: Mainjet 250 (270 without filter) Pilot jet 30 Slide #5 seems to work OK
The M21 settings as you have stated are correct for the 1957 to 1961 M21 as per Amals book so will be fine for any M21.